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As an essential intracellular antioxidant, it plays key roles in maintaining redox balance, supporting nutrient metabolism, and helping protect cells from oxidative stress

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Manual annotation based on canonical markers separated cells into non-endothelial compartments, including stromal (SC), osteoblastic (OB), macrophage (Macro), perivascular (Peri), adipogenic (Adipo), and hematopoietic stem and progenitors (HSPC) and endothelial (ECs) compartments (Fig

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Over the past decade, the understanding of ferroptotic mechanisms has made rapid progress