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However, other studies showed that administration of vitamins C and E both alleviate fibrotic damage in lung tissue, and with a more pronounced effect observed when these two vitamins are combined in rat models (83)

Leptin functions as a hormone to give information about the status of body fat depots by acting on the hypothalamus to diminish food intake and increase energy expenditure to maintain constant adipose tissue mass

These changes contribute to immune cell bioenergetic failure, T cell exhaustion, and cytosolic release of mtDNA, which can activate cGAS-STING and NLRP3 pathways to sustain chronic inflammation

PMC12193160 Bissett, D