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Non-etheless, new compounds or existing drugs await testing as potential therapeutic strategies for PD via improving ETC functions (Singh et al., 2021)

It?s an amino acid used to export fat from the liver to be burned for fuel

These repetitive redox cycles allow for the regeneration of the pools and the maintenance of the cellular redox buffers in a highly reduced state in most cellular compartments under unstressed conditions

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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity