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It has also been observed that after induction by the glucocorticosteroiddexamethasone, which has strong anti-inflammatory, antiallergic, and immunosuppressive effects and is used in dermatology for conditions, such as psoriasis and allergic skin diseases, the expression of CYP1A, CYP2B, CYP2E, and CYP3A is increased at the mRNA level [140, 144]

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Intravenous administration would overcome these problems, as it allows instant circulation of the precursors rather than initial metabolism by the gut microbiota and liver

the liver being the most prominent place of accumulation, as we have already seen)