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Melatonin as a potent and widespread anti-inflammatory agent Several studies have shown that melatonin can regulate the activation of the immune system, reducing chronic and acute inflammation 70,71,72,73

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[207] After the United Kingdom, the following countries and regions expedited processes to approve the PfizerBioNTech COVID19 vaccine for use: Argentina, [208] Australia, [209] Bahrain, [210] Canada, [211] [212] Chile, [213] Costa Rica, [214] Ecuador, [213] Hong Kong, [215] Iraq, [216] Israel, [217] Jordan, [218] Kuwait, [219] Malaysia, [220] Mexico, [221] [222] Oman, [223] Panama, [224] the Philippines, [225] Qatar, [226] Saudi Arabia, [227] [228] [229] Singapore, [230] [231] [232] South Korea, [233] [234] the United Arab Emirates, [235] the United States, [236] and Vietnam

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The repetitive triggering of C-fibers during migraine attacks and the resultant stimulation of CGRP-mediated pain pathways keep the TVS in a state of heightened sensitivity, thus contributing to the progression of migraine into a chronic condition (10, 33)