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Przy problemach z przewodem pokarmowym ta droga podania ma logiczne uzasadnienie

Glutamine, aspartate, and bicarbonate are converted by a single trifunctional, rate-limiting enzyme called carbamoyl phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) to dihydroorotate (40)

This chapter focuses on GR structural features, catalytic mechanism and functional significance during plant development and adaptation to abiotic stresses such as drought, temperature, high light, salt and heavy metals