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Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha

Wang A, et al

C.HuX.HeY.HeR

For many of these approaches, clinical implementation is still far away because of different limitations, as recently reviewed by [6,7]

Although we were successful in ectopically expressing CDO in our cell culture system, the absolute level of maximal expression for either of the CDO constructs was far less than what is normally found in vivo