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However, several indirect mechanisms and associated factors may increase the risk of B12 deficiency in individuals with fatty liver disease

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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

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Gene therapy approaches, such as the use of small interfering RNA or CRISPR-Cas9 systems, could provide a more precise method of inhibiting TGF- signaling at the genetic level (129)