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doi: 10.1073/PNAS.1303060110/SUPPL_FILE/SAPP.PDF 71 MiyataHAshizawaTIizukaAKondouRNonomuraCSuginoTet al

Sattin D

Furthermore, by reducing CCO activity and compromising oxidative phosphorylation, copper deficiency compels cardiomyocytes to rely more heavily on anaerobic glycolysis, thereby reinforcing the metabolic shift that underpins pathological reprogramming [104]