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13 However, in the context of hepatocarcinogenesis, gut flora dysbiosis may shift tryptophan metabolism in a harmful direction

278 Nanoprecipitation is another easy-to-operate method that does not require additional forced energy and can be used to fabricate polymer nanoparticles for a wide range of payloads

Specifically, a JNK signal that is transported to the nucleus phosphorylates c-Jun and other transcription factors, including p53, and then promotes the expression of proapoptotic genes (FasL, TNF , Bim, Bak, etc.), which blocks the transcription of antiapoptotic genes (such as Bcl-2) [73,74,75,76,77,78,79,80]