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Elevated iron levels are also linked to oxidative stress and ferroptosis, a programmed cell death dependent on intracellular ferrous iron and impaired antioxidant defense systems (Ward et al., 2022)

The affinity of SARS-CoV-2 for ACE2 receptors makes the virus prone to cause vascular infection that could explain atherosclerosis progression and arterial and venous thrombosis (270, 271)

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The study showed that amantadine, modafinil, and methylphenidate were not superior to placebo in improving fatigue and were associated with a higher risk of adverse events (39% to 40%) compared with placebo (31%)

If a patient becomes pregnant while receiving NAD+, the treatment would be discontinued unless there were extraordinary circumstances and a careful risk-benefit assessment by the healthcare provider