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These activated KCs exert a core pathogenic role in the cytokine-mediated various inflammation cascades [34,35,36], not merely serving as immune response triggers but also as proinflammatory non-immune cell effectors, which are capable of amplifying cytokine signal pathways from innate and adaptive immune cells to create a self-perpetuating autoimmune cytokine loop further so that persisting inward recruitment of leukocytes subsets into psoriatic lesions [37,38,39], e.g., macrophages, neutrophils, myeloid DCs and T subsets

Meister, J

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6A, B) in microglia in the SN of MPTP-treated mice

Pharmaceutics 14:1372 Chida T, Miura Y, Cabral H, Nomoto T, Kataoka K, Nishiyama N (2018) Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release