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The severity of the cartilage damage was evaluated through both morphological and histopathological analysis, and the degree of lameness was observed 8 weeks after the beginning of the trial

5 Pipeline Strategies Targeting FcRn There are currently five FcRn antagonists in active clinical development and several publicly disclosed protein-based molecules in pre-clinical stages with plans for clinical studies within 20252026

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The mev-1 gene, encoding Cyt-1a key component of complex II in the mitochondrial ETChas been implicated in excessive oxidative stress associated with ocular surface epithelial damage and reduced tear production in a Tet-mev-1 conditional transgenic mouse model

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