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J Immunol (2020) 204:213342

Homocysteine further impacted a specific protein, syntaxin 17, which is critical for removing damaged cells from the body, a process called autophagy

The main exception to this rule is the GLP-1 class (like semaglutide, tirzepatide, or retatrutide), which may be used for longer under proper supervision since the studies and pharmacology support extended duration