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Complementary to the above, it has been thought for a long time that only supraphysiological concentrations of IGF-1 are able to activate the IR, as will be further discussed in this manuscript

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BMP-2 and Sonic Hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells

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According to general procedure A, the title compound was obtained as yellow powder (58% yield)