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etanercept and infliximab that target tumor necrosis factor alpha (TNF) [] and kinase inhibitors including dasatinib and ruxolitinib, which limit CRS by suppressing cytokine production [ , ]

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Electrophysiological recordings combined with high-performance liquid chromatography analyses have demonstrated that NRN1 treatment enhances presynaptic glutamate release and increases spontaneous miniature excitatory postsynaptic current frequency in neurons of the medial prefrontal cortex in mice (Lu et al., 2017)

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