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It is built on a 37-residue modified human amylin / pramlintide-style backbone with three rationally designed substitutions (N14E and V17R to stabilise the central alpha-helix through a salt bridge, P37Y to enhance calcitonin-receptor potency) and N-terminal acylation with a C20 eicosanedioic fatty diacid attached via a gamma-glutamic acid linker

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(2) Silybum marianum extract (70%80% silymarin), 225 mg

doi:10.1016/j.msec.2018.10.093 157

Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation