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The delivery strategy used in this study, including a novel nanoformulation and an orobuccal administration, may be effective in improving the magnitude of absorption of other modulators of oxidative stress known to have limited bioavailability, such as resveratrol [22]

Reduction of oxidative stress in peripheral blood mononuclear cells attenuates the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis

Furthermore, whilst this study has shown higher glutathione levels in ME/CFS, there are studies that suggest that glutathione levels in ME/CFS are lower which also fits the picture of oxidative stress demonstrated

doi: 10.1006/phrs.1997.0134

This is especially true given that many of the translational demands for small, direct-acting molecules are unlikely to align with the alternative development pathways