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In vivo , ADO concentrations in BM plasma remained consistently in the micromolar range and declined only modestly during treatment, whereas INO progressively increased, leading to a gradual attenuation of the BM -PB gradient

Clinical observations in 51 pediatric patients

Thus, a higher glutamine/glutamate ratio reinforces the substrates availability for GSH synthesis [39]

& Grohovaz, F

Second, the amide and amino groups of Gln act as nitrogen sources for the synthesis of non-essential amino acids, nucleotides, and amino sugars, which are vital for cell proliferation [5,6]