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Furthermore, CPI-613 suppresses the proliferation of multiple myeloma cells by inducing mitochondrial metabolic dysfunction through the targeting of pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1) and oxoglutarate dehydrogenase (OGDH), and it produces significant anti-tumor effects when combined with bortezomib at a lower dose [88]

Apoptosis has two pathways to be carried out, one that is considered internal, in which various families of proteins are implicated, and a second pathway, in this case external, in which different ligands bind to specific receptors (107)

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