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Indirect Evidence for A Role of Redox Dysregulation in Als As well as the studies described above, there is also evidence that cellular processes associated with redox homeostasis are dysregulated in ALS (Figure 2)

Waglerin-1 (H-Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys-His-Pro-Pro-Cys-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH), for example, is a peptide isolated from the venom of the temple viper, Tropidolaemus wagleri

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84 Additionally, lactylation of SORBS3, especially at lysine 479, abolishes its LLPS, which enhances its interaction with flotillin 1 and selectively sorts FBXO2 into lactate bodies, leading to hepatocyte apoptosis, activation, and liver fibrosis