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While the presence of the enolases seen in schistosomulae have been confirmed in adults, a bevy of other possible anti-coagulation mechanisms have been identified in adult worms

In addition, we do not know whether co-injections of L-NAC or L-NACme alter the antinociception actions of fentanyl (e.g., analgesia, expected tolerance, and occurrence of hyperalgesia), although we have reported that (a) bolus injections of L-NAC do not impair analgesia induced by continuous infusion of fentanyl in rats, despite reversing fentanyl-induced OIRD 20 , and (b) bolus injections of other L-D-thiolesters, such as D-cysteine di(m)ethyl ester, L- or D-cysteine (m)ethyl esters, and L-glutathione ethyl ester, prevent/overcome the actions of fentanyl and morphine on ventilatory parameters, and arterial blood-gas chemistry in rats without compromising opioid-induced analgesia or sedation 36

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