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Results: ASO induced PKM splice switching and inhibited the growth of cultured HCC cells, and increased pyruvate-kinase activity and altered glucose metabolism

As explained later, these components can cross-talk with other pathways such as the MAPK/ERK1/2 (mitogen activated protein kinase/extracellular signal-regulated kinase 1/2) and PI3/Akt (phosphoinositide 3-kinase/protein kinase B) signaling cascades causing changes in gene expression and modifying cell metabolism and proliferation (47)

Alivernini, S., Firestein, G

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