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10.1038/s41420-021-00579-w 184 ZangH.WuW.QiL.TanW.NagarkattiP.NagarkattiM.et al (2020)

The IRE1 signaling pathway, a highly conserved component of the UPR, is a transmembrane protein in the endoplasmic reticulum with two enzymatic activities: protein kinase and endoribonuclease [15,16,17,18,19,20,21,22,23]

It is important to note that sexual function is influenced by a multitude of factors, including psychological, neurological, endocrine, and vascular abnormalities, which cannot be solely ascribed to sex hormone levels

& Iwata, N

The relative infrequency of studies undertaken within the Valley of Death DRLs 46 can hinder the development of ITD system designs across the full design arc from conceptualization (DRL-1) to real-word deployment (DRL-9)