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Mifepristone, a glucocorticoid receptor (GR) antagonist, exerts its therapeutic effects by blocking GR, thereby rectifying HPA axis overactivation, restoring negative feedback regulation, and lowering cortisol levels

G., Fu C

Crohns Colitis 2 , otaa023 (2020)

ROS signaling regulates transcription factors, such as AP-1 and nuclear factor-kappa B (NF-B), inducing the expression of matrix metalloproteinases (MMPs) that can induce collagen oxidation and reduce the expression of types I and III collagen [26]