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Vitamine C kan de effectiviteit van opioden versterken, waardoor lagere doseringen nodig kunnen zijn en bijwerkingen afnemen.(118,119) Hoge doseringen vitamine C kunnen bovendien ontwenningsverschijnselen bij opiodengebruik reduceren.(120) De pijnstillende werking wordt deels toegeschreven aan de antioxidatieve en ontstekingsremmende eigenschappen van vitamine C, waardoor ontstekingsprocessen en weefselschade worden geremd

Nat Commun 2024;15(1):7323

Gautier EL, Huby T, Witztum JL, Ouzilleau B, Miller ER, Saint-Charles F, Aucouturier P, Chapman MJ, Lesnik P (2009) Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage

The study challenges the notion of redox compartmentalization in MLOs, suggesting that their redox environment mirrors that of their surroundings, likely due to the lack of physical barriers and similar partitioning of GSH and GSSG.