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Notably, as displayed in Supplementary Fig

Every assessment of this combination relies on extrapolation from animal pharmacology, known apixaban metabolism pathways, and pharmacodynamic reasoning about vascular effects

Glutathione S-conjugates are usually sequestered by distinct ABC transporters from the cytosol into the vacuole for degradation, although breakdown of glutathione, oxidized glutathione and glutathione S-conjugates also happens outside the vacuole 56

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