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In animal models of traumatic brain injury, increased ICP leads to increased neuronal injury and behavioral changes, even without global ischemia

However, theyre not a magic bullet and should be used with a healthy lifestyle for optimal results

No human clinical trials in stroke or TBI populations have been published

Nature 630 , 720727 (2024)

The clinical effects relevant to weight loss include increased lipolysis (fat breakdown, particularly visceral and abdominal fat), preservation of lean muscle mass during caloric deficit, improved recovery from exercise, enhanced sleep quality (GH is released primarily during deep sleep), and improved metabolic rate at rest