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Selected Preclinical Data Study 1: Genetic Proof-of-Concept A seminal investigation reported elevated NNMT expression in white adipose tissue (WAT) and liver of obese/diabetic mice

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In laboratory studies, 5-Amino-1MQ has been evaluated for its interaction with nicotinamide N-methyltransferase (NNMT)-associated enzymatic pathways and downstream NAD+-related and methylation signaling under controlled experimental conditions

5-Amino-1MQ operates at the cellular level, inhibiting NNMT and boosting NAD+ to optimize mitochondrial function and promote fat oxidation

Notably, these interactions are speculated to be achieved through oxidative pathways and may occur independently of the HGH receptor in these models