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Furthermore, using both inhibitors and RNA silencing we have shown that TGR is an essential schistosome protein, and we believe that our results have validated it as a key drug target for treatment of schistosomiasis

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However, in obesity, excessive weight gain leads to white adipose tissue dysfunction, resulting in unregulated secretion of adipokines, including pro-inflammatory ones, fostering a chronic low-grade inflammatory state (99)

Conversely, it appears that the IMM prevents rapid equilibration of the IMS and matrix glutathione pools