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A study by Sinha et al

8 Hypoxemia is a well-known primary cause of high-altitude illness among many visitors, sojourners, and natives

Apart from exacerbating local inflammation, TNF- can activate the NF-KB and MAPK signaling pathways, increasing cellular susceptibility to oxidative stress and weakening GPX4 and other antioxidant enzymes, thereby promoting further accumulation of lipid peroxidation byproducts and markedly elevating ferroptosis risk (119)