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Moreover, inhibition of the C5a-C5aR axis by using the C5 antibody diminished cerebral lesion and improved motor functions in a rat model of stroke [55], and treatment with C5a receptor antagonistPMX53 significantly decreases ischemia-induced apoptosis of primary mouse cortical neurons subjected to oxygenglucose deprivation (an in vitro model of hypoxiaischemia) [56]