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Reducing the use and concentration of chemotherapeutic agents through combination therapy represents a key step towards less toxic treatments

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For example, IRE delivers high-voltage electric pulses to disrupt cellular membrane integrity, inducing immunogenic cell death (ICD) through damage-associated molecular pattern (DAMP) release and loss of intracellular homeostasis ( + T-cell infiltration ( + T-cell quality/quantity and extend survival ( + T-cell conversion to antitumor Th1/Th17 subsets in MHC-I-low PDAC, where subsequent PD-L1 blockade activates compensatory cDC2-CD4 + T-cell axes ( 3.2 Hepatocellular carcinoma Clinical studies have established IRE as a safe and effective hepatocellular carcinoma (HCC) ablation modality, with ongoing optimization of efficacy assessment methods and device engineering complementing robust evidence of its antitumor effects

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