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Neuroinflammation or fever is presumed to also trigger ISR, as autoantibodies may target neural or immune systems and cause inflammation elsewhere (418)

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Abbreviations 7nAChRs: Alpha-7-nicotinic acetylcholine receptors A: Amyloid- AD: Alzheimers disease ASD: Autism spectrum disorder ACh: Acetylcholine Akt: Protein kinase-B Bax: Bcl-2-associated X protein Bcl-2: B-cell lymphoma-2 CNS: Central nervous system DhE: Dihydro--erythroidine GABA: Gamma-aminobutyric acid GSH: Glutathione GPX: Glutathione peroxidase Hg: Mercury IL-1: Interleukin-1 MDA: Malondialdehyde MLA: Methyllycaconitine NF-B: Nuclear factor kappa B Nfr2: Nuclear factor erythroid 2related factor 2 NO: Nitric oxide NDDs: Neurodevelopmental disorders NMDA: N -methyl-D-aspartate PI3K: Phosphoinositide 3-kinases PV: Parvalbumin ROS: Reactive oxygen species TNF-: Tumor necrosis factor-alpha WHO: World Health Organization References Hodges H, Fealko C, Soares N (2019) Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation