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Extracellular vesicles (EVs) are released from a variety of cells and contain a plethora of bioactive molecules, including proteins and RNAs and are important mediators of intercellular communication

In PD, a ketogenic diet trial (very high fat, low carbohydrate) is underway, hypothesizing shifts in the microbiome/metabolome (elevated ketones and possibly Akkermansia ) with potential motor benefits [236]

The 21-day feeding period was selected to model sub-chronic dietary exposure and is sufficient to elicit measurable behavioral, neurochemical, and oxidative alterations in rodent models

Jorgensen, W

We thank Marisa Jakobs for the help with initial redox mobility shift assays and Robin Schumann for cloning wild-type and mutant ROGFP2