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And somehow, it touches collagen production, wound healing, antioxidant activity, and the expression of thousands of genes at the same time

Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients

The updated 2018 diagnostic criteria for PCOS require the presence of at least two of the following three features: (1) oligo/anovulation, (2) clinical and/or biochemical hyperandrogenism, and (3) PCO identified by the presence of 20 antral follicles per ovary on transvaginal ultrasound, with or without increased ovarian volume

The N-terminal GSDMD fragment creates transmembrane pores, leading to the initiation of pyroptotic cell death

This work was supported by the National High Level Hospital Clinical Research Funding (Grant number 2023-NHLHCRF-BQ-25) and the National Natural Science Foundation of China (Grant number 22278449)