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This may be explained by differences in body composition and should be taken into account when dosing or following factor VIII levels in the pediatric population.4 Because clearance (based on per kg body weight) has been demonstrated to be higher in the pediatric population, dose adjustment or more frequent dosing based on per kg body weight may be needed in this population [see Clinical Pharmacology (12.3)]

Abbreviations ADFI: Average daily food intake ADG: Average daily weight gain BCS: Body condition score BF: Backfat depth BW: Body weight CRL: Crown-rump length CV BW : Coefficient of variation of birth weight DS: Piglet diarrhea score IUGR: Intrauterine growth retardation LBW: Low birth weight LD: Lipid droplets LDA: Linear discriminant analysis NAD: Nicotinamide adenine dinucleotide NAMPT: Nicotinamide phosphoribosyl transferase NadR: NA/NAM riboside kinase NA: Niacin NAM: Nicotinamide NR: Nicotinamide riboside RT: Rectal temperature SCFAs: Short-chain fatty acids TFI: Total food intake References Muro BB, Carnevale RF, Leal DF, Almond GW, Monteiro MS, Poor AP, et al

Once the opening date is missing, the status of the vial becomes much harder to defend

The treatment protocol involves multiple injections over time, as determined by healthcare providers based on individual patient needs

doi: 10.1016/j.neurot.2023.10.002 111 KohliR