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Enhanced fat oxidation and improved energy availability

doi: 10.1111/hel.12335 28 CensiniSSteinMCovacciA

Peer review Peer review information Nature Chemical Biology thanks Rudi Fasan and the other, anonymous reviewer(s) for their contribution to the peer review of this work

GCL, heterodimer made up of the heavy sub unit (73 kDa) has the catalytic activity (GCLC), and is the site of GSH feed back inhibition The light (30 kDa) or modifier (GCLM) sub unit, alter, or regulate the activity of the holoenzyme Glutamate cysteine ligase (GCL) L-glutamate + L-cysteine + ATP -L-glutamyl-L-cysteine + ADP + Pi GCL is regultate physiologically by : Feed back competitive inhibition by GSH The availability of its precurser, L-cysteine