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The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months

The effects of collagen peptide, supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: systematic review. Khatri, Naughton, Clifford

AOD-9604 Stacking: Combinations That Users Report Because AOD-9604 targets a single pathway (beta-3 adrenergic lipolysis), many users combine it with peptides that address complementary mechanisms

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The 14-member committee prior to the meeting added seven people who operate or work for clinics or businesses selling peptide treatments