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After absorption into enterocytes, soluble curcumin and its metabolites face two potential pathways: efflux back into the intestinal lumen via transporters, such as MRP2, BCRP, and P-gp, or movement into the portal blood through MRP1 and MRP3 transporters (92, 121)

These findings clearly show that GPX1 is irreplaceable by other selenoproteins in protecting against systemic oxidative stress, and GPX1 has a significant antioxidant function in the body ( FIGURE 1 On the surface, the mice after GPX1 KO performed normally, but these mice were susceptible to the production of oxidative substances, and when stimulated, they were easy to cause harm to mice and increase oxidative stress in vivo

Of the original group, 169 were positive for thyroid peroxidase (TPO) antibodies and were divided into two groups: 77 pregnant women received 200 mcg of selenomethionine a day, and 74 received placebo doses

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