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In high-glucose environments, the retina, a tissue with significant oxygen demand, is especially susceptible to injury

Cho S, Lee YH, Park H et al (2001) Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

When there is a disruption or blockage in the blood vessels supplying the brain, it can lead to various vascular disorders like stroke and vascular dementia (10)

16.Miere F, Fritea L, Cavalu S, Vica SI

(v) alternatively, pyruvate may yield acetate through neomorphic activity of pyruvate dehydrogenase complex (or other dehydrogenases) in the presence of reactive oxygen species (ROS) 169,170 , that in turn yields acetyl-CoA by mitochondrial acetyl-CoA synthetase (Fig