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Changes in the BBB associated with Alzheimer's disease primarily include endothelial abnormalities such as reactive gliosis, mitochondrial damage, alterations in the extracellular matrix, disrupted tight junctions, and both molecular and functional changes in astrocytes

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Sikiric et al., 2020a) may contrast with the miscellaneous underlying fistula causes, various origin and location and different occurrences (Orangio, 2010