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The presence of 5hmC in the genome causes the passive loss of DNA methylation upon DNA replication, given that DNMT1 is unable to recognize hemi-methylated 5hmC sites (Otani et al., 2013)

[675] Commenters stated they understood why CMS was considering a measure addressing COVID-19 vaccination coverage among patients, but noted CMS should postpone considering this measure since the definition of fully vaccinated is evolving

FFPE lung sections from five IPF patients were obtained from the KU Leuven lung biobank (ethical approval S52174)

Nausea and Vomiting Instruct patients experiencing grade 2 nausea (food intake significantly decreased but able to eat intermittently) or greater to stop taking XELODA and to immediately contact their healthcare provider for management of nausea [see Adverse Reactions (6.1)]