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Delgado-Bellido, D., Serrano-Saenz, S., Fernndez-Corts, M

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In parallel with an increase in GSTA1 and a decrease in TG level after transfection with the GSTA1 plasmid in OA-treated L02 cells, gene expression involved in the esterification of FA to TG (endoplasmic reticulum-bound stearoyl-CoA desaturase 1 ( SCD1 ), glycerol-3-phosphate acyltransferase 3 ( GPAT3 ), LIPIN and diacylglycerol acyltransferase 1/2 ( DGAT1 , DGAT2 ), FA de novo lipogenesis (acetyl-coenzyme A synthetase 2/3 ( ACSS2 , ACSS3 ), sterol response element-binding protein 1 ( SREBP1 ) and fatty acid synthase ( FAS )), and FA -oxidation (carnitine palmitoyltransferase 1 alpha ( CPT1A ), acyl Co-A oxidase ( ACOX1 ) and acetyl Co-A carboxylase 2 ( ACC2 )) were decreased in a dose-dependent manner (Figure 6CE)

The acidic environment created by the accumulation of lactate and CO2 degrades IFN-, weakening the differentiation of naive T cells into anti-tumor Th1 cells, while promoting their differentiation into pro-tumor Th2 cells