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A deficiency in B12 can lead to feelings of irritability, anxiety, and even depression

Tada, Y., Nakaya, R., Goto, S., Yamashita, Y

It can shape a profoundly immunosuppressive TME by inducing the expansion of myeloid cells, enhancing the suppressive function of Tregs, or directly driving CD8 + T cells toward terminal exhaustion, thereby undermining the efficacy of various immunotherapies [292,293,294,295,296]

This, in turn, enhances the drug efficacy while reducing the risk of systemic toxicity, as it helps prevent rapid burst release and minimizes the need for repeated dosing (Natarajan et al., 2014

In Nederland en Belgi is er steeds meer aandacht voor de lichamelijke kant van autisme, maar lang niet alle artsen zijn bekend met mitochondriale problematiek