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Description

Problem Fibromyalgia is a nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points)

Predictability of covalent binding of acidic drugs in man

This occurs when damaged brain cells release too much glutamate

Valproic acid and hyperammonaemia Although ammonia is produced in all cells, the majority is produced in the gastrointestinal tract (via bacterial breakdown of circulating urea, breakdown of circulating glutamine and deamination of ingested proteins), skeletal muscle (after physical activity or seizures and due to amino acid metabolism) and the kidney (via deamidation of adenosine monophosphate)