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Building on the redox-linker strategies described earlier, scaffold design leverages disulfide- and boronate-based networks to achieve tunable degradation and on-demand GSH release

Toxicology 464, 153027

1 The exportin-1 inhibitor selinexor was evaluated in the phase 3 BOSTON study of selinexor, bortezomib, and dexamethasone therapy administered once weekly versus twice weekly doublet therapy with bortezomib and dexamethasone

The cultures were left to grow at 37 C until the OD 600 reached 0.6 and were then induced with 0.5 mM IPTG at 30 C for 12 h

Stress can increase acid production and slow digestion, which may worsen symptoms