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10.1038/cdd.2010.80 Cell Death Differ

27,28 Because of an association between HT and celiac disease, a low gluten diet has been suggested as potentially modulating HT

Alternatively, cancer cells may rely on ATF4-mediated stress mechanisms to bypass these inhibitors

This association is mediated through dysregulated iron metabolism, lipid peroxidation, and key signaling pathways, including the System Xc-/GSH/GPX4 axis, GCH1/BH4/DHFR pathway, and FSP1/CoQ10/NADH system