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[20] ROS can form as a result of drought, injury, herbicides and pesticides, ozone, plant metabolic activity, nutrient deficiencies, photoinhibition, temperature above and below ground, toxic metals, and UV or gamma rays

Wang S, Zhou Y, Yu R, Ling J, Li B, Yang C, et al

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CD25 upregulation is associated with the expression of regulatory T cells (Treg), which play a crucial role in immunological tolerance by suppressing immune response generation and activating CD8+ cells and NK cells, thus aiding in immune escape (70, 71)

As individuals age, imbalances in gut bacteria lead to the release of proinflammatory microbial products due to compromised intestinal permeability ( Cell senescence Some scholars have proposed that cellular senescence may be the driver of skin aging