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Editors Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinsons Disease Risk

Stem cell Res 11:13481364 Hao N-B, Li C-Z, L M-H, Tang B, Wang S-M, Wu Y-Y, Liang G-P, Yang S-M (2015) SDF-1/CXCR4 axis promotes MSCs to repair liver injury partially through trans-differentiation and fusion with hepatocytes

Overall, our data implicate a strong dependence of cancer cells expressing the active AKT-E17K mutant on their enhanced GSH levels for protection against ROS and cell survival, though the TrX system and ROS-detoxifying enzymes (SOD1, catalase) might still be relevant for the maintenance of antioxidant capacity in TrC1 AKT-E17K cells

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An important next step in advancing this framework will be the direct characterization of mitochondria-centered organelle interactions during ovarian aging